BDBM314694 US10513522, Example 7::US11214573, Example 7::US9611269, Example 7

SMILES CN(C1CC1)C(=O)c1ccc(N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1

InChI Key InChIKey=DEKSDVKVZJYQOT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 314694   

TargetTyrosine-protein kinase JAK1(Human)
Incyte

US Patent
LigandPNGBDBM314694(US9611269, Example 7 | US10513522, Example 7 | US1...)
Affinity DataIC50: 10nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Incyte

US Patent
LigandPNGBDBM314694(US9611269, Example 7 | US10513522, Example 7 | US1...)
Affinity DataIC50: 10nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Incyte

US Patent
LigandPNGBDBM314694(US9611269, Example 7 | US10513522, Example 7 | US1...)
Affinity DataIC50: 10nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Incyte

US Patent
LigandPNGBDBM314694(US9611269, Example 7 | US10513522, Example 7 | US1...)
Affinity DataIC50: 10nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte Holdings

US Patent
LigandPNGBDBM314694(US9611269, Example 7 | US10513522, Example 7 | US1...)
Affinity DataIC50: 10nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), JAK2 (a.a. 828-1132) and JAK3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte Holdings

US Patent
LigandPNGBDBM314694(US9611269, Example 7 | US10513522, Example 7 | US1...)
Affinity DataIC50: 10nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), JAK2 (a.a. 828-1132) and JAK3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent