BDBM314627 (5-methyl-3-pyrimidin-2-yl-2-pyridyl)-[(1R,2R,4S,5R)-2-methyl-5-[[5-(trifluoromethyl)-2-pyridyl]oxy]-3-azabicyclo[2.2.2]octan-3-yl]methanone::US9611262, Example 161

SMILES CC1C2CCC(C(C2)Oc2ccc(cn2)C(F)(F)F)N1C(=O)c1ncc(C)cc1-c1ncccn1

InChI Key

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 314627   

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM314627((5-methyl-3-pyrimidin-2-yl-2-pyridyl)-[(1R,2R,4S,5...)
Affinity DataKi:  4nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM314627((5-methyl-3-pyrimidin-2-yl-2-pyridyl)-[(1R,2R,4S,5...)
Affinity DataKi:  8nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM314627((5-methyl-3-pyrimidin-2-yl-2-pyridyl)-[(1R,2R,4S,5...)
Affinity DataKi:  5.00E+3nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent