BDBM31459 CHEMBL224485::substituted biphenyl derivative, 21

SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccccc1C(=O)Nc1ccc(cc1)C(N)=N

InChI Key InChIKey=OPEFANHGJWQXDF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 31459   

TargetCoagulation factor VII(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50: 120nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Biocryst Pharmaceuticals

LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50: 170nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50: 6.40E+4nMT: 2°CAssay Description:Thrombin assay reactions were performed in a reaction mixture containing thrombin, and test compounds were added at varied concentrations. The reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50: 1.03E+5nMT: 2°CAssay Description:Thrombin assay reactions were performed in a reaction mixture containing thrombin, and test compounds were added at varied concentrations. The reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50: 89nMAssay Description:Inhibition of human TF/FVIIa complex by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50: 880nMAssay Description:Inhibition of human Fxa by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed