BDBM313752 US10167282, Compound TBAP-03

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=NVVFIJVZWGYGQT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 313752   

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM313752(US10167282, Compound TBAP-03)
Affinity DataIC50: 130nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM313752(US10167282, Compound TBAP-03)
Affinity DataIC50: 19nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM313752(US10167282, Compound TBAP-03)
Affinity DataIC50: 1.00E+5nMAssay Description:Studies were conducted at Cyprotex Discovery in Cheshire, UK according to the contractor's protocol. The studies were performed on an IonWorks HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent