BDBM313695 N-(3-(2-(4-amino-4-methylpiperidin-1-yl)-6-(tetrahydro-2H-pyran-4-yl)pyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide::US10167279, Example 321

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(nc(c1)N1CCC(C)(CC1)NC(=O)OC(C)(C)C)C1CCOCC1

InChI Key InChIKey=PXXSMUPFTDZXSL-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313695   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis

US Patent

LigandBDBM313695(US10167279, Example 321 | N-(3-(2-(4-amino-4-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 90nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/24/2019
Entry Details
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