BDBM313443 US10167270, Example 140

SMILES C(COCc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1

InChI Key InChIKey=BBJKIYCPVMDVEB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313443   

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM313443(US10167270, Example 140)
Affinity DataIC50: 1.12E+4nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetLysosomal acid glucosylceramidase(Human)
Northwestern University

US Patent
LigandPNGBDBM313443(US10167270, Example 140)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of wild type recombinant human lysosomal beta-glucocerebrosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed