BDBM313183 US10166249, Example 694::US11058696, Example 694

SMILES COc1cccc(CCC2CCc3cc(ccc3C2)[C@H]2CC[C@@](N)(COP(O)(O)=O)C2)c1

InChI Key InChIKey=OPWNVYPWPMIBGP-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 313183   

TargetSphingosine-1-phosphate lyase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313183(US10166249, Example 694 | US11058696, Example 694)
Affinity DataEC50:  38.6nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313183(US10166249, Example 694 | US11058696, Example 694)
Affinity DataEC50: >1.25E+3nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Mouse)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313183(US10166249, Example 694 | US11058696, Example 694)
Affinity DataEC50:  38.6nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313183(US10166249, Example 694 | US11058696, Example 694)
Affinity DataEC50: >1.25E+3nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent