BDBM313124 1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpiperidin-3-yloxy)phenyl)-1H-1,2,4-triazole-3,5-diamine::US10166216, Compound 153

SMILES COc1cc2ncnc(-n3nc(Nc4ccc(OC5CCCN(C)C5)cc4)nc3N)c2cc1OC

InChI Key InChIKey=PCYJKTXTSLEFDF-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 313124   

TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM313124(US10166216, Compound 153 | 1-(6,7-dimethoxyquinazo...)
Affinity DataIC50: 1.00E+3nMAssay Description:The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM313124(US10166216, Compound 153 | 1-(6,7-dimethoxyquinazo...)
Affinity DataEC50:  52nMAssay Description:Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM313124(US10166216, Compound 153 | 1-(6,7-dimethoxyquinazo...)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM313124(US10166216, Compound 153 | 1-(6,7-dimethoxyquinazo...)
Affinity DataEC50:  4nMAssay Description:Inhibition of VEGF stimulated VEGFR2 phosphorylation at Y165 residues in HUVEC preincubated for 1 hr followed by VEGF addition measured after 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed