BDBM313086 1-(2-methylquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-1,2,4-triazole-3,5-diamine::US10166216, Compound 65

SMILES Cc1nc(-n2nc(Nc3ccc(OCCN4CCCC4)cc3)nc2N)c2ccccc2n1

InChI Key InChIKey=SDEYRLBSHUAVTK-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 313086   

TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM313086(US10166216, Compound 65 | 1-(2-methylquinazolin-4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetInsulin receptor(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM313086(US10166216, Compound 65 | 1-(2-methylquinazolin-4-...)
Affinity DataEC50:  320nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM313086(US10166216, Compound 65 | 1-(2-methylquinazolin-4-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM313086(US10166216, Compound 65 | 1-(2-methylquinazolin-4-...)
Affinity DataEC50:  52nMAssay Description:Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2020
Entry Details Article
PubMed