BDBM312939 Ex. 64 of US 8198269::US9605007, Comparator 5

SMILES NC1=N[C@]2(COCC[C@H]2CS1)c1cc(NC(=O)c2ccc(cn2)C#N)cs1

InChI Key InChIKey=LAOKNTCIMWLGDD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312939   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM312939(US9605007, Comparator 5 | Ex. 64 of US 8198269)
Affinity DataIC50: 19nMAssay Description:The BACE1 and BACE2 binding assays measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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LigandPNGBDBM312939(US9605007, Comparator 5 | Ex. 64 of US 8198269)
Affinity DataIC50: 1.80E+3nMAssay Description:All testing was carried out in CHO cells transfected with the hERG gene purchased from Millipore (PrecisION hERG-CHO Recombinant Cell Line CYL3038). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent