BDBM31244 isoindolinone scaffold, 33

SMILES CC(C)(C)c1ccc(COC2(N(CCc3cnc[nH]3)C(=O)c3ccccc23)c2ccccc2)cc1

InChI Key InChIKey=BUZRFRDGCQIKFD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31244   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Newcastle Upon Tyne

LigandPNGBDBM31244(isoindolinone scaffold, 33)
Affinity DataIC50: 2.14E+5nMpH: 7.4 T: 2°CAssay Description:For initial testing, the compounds and controls were plated out in triplicate into clear 96-well plates (Nunc) in 10 ul aliquots to give final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed