BDBM312072 3-(6-chloro-5-fluoro-1H- indol-3-yl)pyrrolidine- 2,5-dione::US9603836, Compound 7::US9949951, 7

SMILES Fc1cc2c(c[nH]c2cc1Cl)C1CC(=O)NC1=O

InChI Key InChIKey=HXMKSWGNEVHRHC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 312072   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM312072(US9603836, Compound 7 | 3-(6-chloro-5-fluoro-1H- i...)
Affinity DataIC50: 490nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM312072(US9603836, Compound 7 | 3-(6-chloro-5-fluoro-1H- i...)
Affinity DataIC50: 490nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM312072(US9603836, Compound 7 | 3-(6-chloro-5-fluoro-1H- i...)
Affinity DataIC50: 490nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed