BDBM312064 (-)-(R)-3-(1H-indol-3- yl)pyrrolidine-2,5-dione::US9603836, Compound 4::US9949951, 4

SMILES O=C1C[C@@H](C(=O)N1)c1c[nH]c2ccccc12

InChI Key InChIKey=VNQNEQQYAIPCAQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 312064   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM312064(US9603836, Compound 4 | (-)-(R)-3-(1H-indol-3- yl)...)
Affinity DataIC50: 1.80E+3nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM312064(US9603836, Compound 4 | (-)-(R)-3-(1H-indol-3- yl)...)
Affinity DataIC50: 1.80E+3nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Iteos Therapeutics

Curated by ChEMBL
LigandPNGBDBM312064(US9603836, Compound 4 | (-)-(R)-3-(1H-indol-3- yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Iteos Therapeutics

Curated by ChEMBL
LigandPNGBDBM312064(US9603836, Compound 4 | (-)-(R)-3-(1H-indol-3- yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Iteos Therapeutics

Curated by ChEMBL
LigandPNGBDBM312064(US9603836, Compound 4 | (-)-(R)-3-(1H-indol-3- yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Iteos Therapeutics

US Patent
LigandPNGBDBM312064(US9603836, Compound 4 | (-)-(R)-3-(1H-indol-3- yl)...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Iteos Therapeutics

Curated by ChEMBL
LigandPNGBDBM312064(US9603836, Compound 4 | (-)-(R)-3-(1H-indol-3- yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Iteos Therapeutics

Curated by ChEMBL
LigandPNGBDBM312064(US9603836, Compound 4 | (-)-(R)-3-(1H-indol-3- yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2020
Entry Details Article
PubMed