BDBM31172 3-hydroxyquinolin-2(1H)-one, 26

SMILES Oc1cc2c(Cl)c(F)ccc2[nH]c1=O

InChI Key InChIKey=SJNYFCFQCNCHDD-UHFFFAOYSA-N

Data  6 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 31172   

TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: 5nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2009
Entry Details Article
PubMed
TargetD-aspartate oxidase(Human)
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: 4.32E+4nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2009
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Rat)
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: 50nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2009
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Human)
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataKd:  4.60nMAssay Description:Binding affinity to human recombinant DAAO by steady state study scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Healthcare Products

Curated by ChEMBL
LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD-aspartate oxidase(Bovine)
Abbott Healthcare Products

Curated by ChEMBL
LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed