BDBM311561 2-[(2- aminoethyl)amino]-N- [3-carbamoyl-1-(2- hydroxyethyl)-1H- pyrazol-4- yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10155765, Example 59

SMILES NCCNc1ncc2ccc(C(=O)Nc3cn(CCO)nc3C(N)=O)n2n1

InChI Key InChIKey=QPVZWGQOGXCQPL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 311561   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM311561(US10155765, Example 59 | 2-[(2- aminoethyl)amino]-...)
Affinity DataIC50: 2nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM311561(US10155765, Example 59 | 2-[(2- aminoethyl)amino]-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human GST-tagged IRAK4 incubated for 30 mins in presence of ATP by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed