BDBM311543 N-(3-carbamoyl-1-pyridin-4- yl-1H-pyrazol-4-yl)-5- piperazin-1-ylpyrazolo[1,5- a]pyrimidine-3-carboxamide trifluoroacetate::US10155765, Example 34

SMILES NC(=O)c1nn(cc1NC(=O)c1cnn2ccc(nc12)N1CCNCC1)-c1ccncc1

InChI Key InChIKey=YNVUCDCUQVKWLX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311543   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM311543(US10155765, Example 34 | N-(3-carbamoyl-1-pyridin-...)
Affinity DataIC50: 25nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent