BDBM311536 5-{[(1R,2S)-2- aminocyclohexyl]amino}- N-{3-carbamoyl-1-[(1- methylpiperidin-3- yl)methyl]-1H-pyrazol-4- yl}pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10155765, Example 25

SMILES CN1CCCC(Cn2cc(NC(=O)c3cnn4ccc(N[C@@H]5CCCC[C@@H]5N)nc34)c(n2)C(N)=O)C1

InChI Key InChIKey=XYEFAMKTWBRGIR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311536   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM311536(US10155765, Example 25 | 5-{[(1R,2S)-2- aminocyclo...)
Affinity DataIC50: 2nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent