BDBM311532 5-{[cis-2- aminocyclohexyl]amino}- N-{3-carbamoyl-1-[1- (methylsulfonyl)piperidin- 3-yl]-1H-pyrazol-4- yl}pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10155765, Example 20

SMILES CS(=O)(=O)N1CCCC(C1)n1cc(NC(=O)c2cnn3ccc(N[C@H]4CCCC[C@H]4N)nc23)c(n1)C(N)=O

InChI Key InChIKey=ROLVPPMVMFARPG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311532   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM311532(US10155765, Example 20 | 5-{[cis-2- aminocyclohexy...)
Affinity DataIC50: 4nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
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Date in BDB:
4/10/2019
Entry Details
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