BDBM311518 5-{[cis-3-amino-1,1- dioxidotetrahydro-2H- thiopyran-4-yl]amino}- N-(3-carbamoyl-1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10155765, Example 4

SMILES Cn1cc(NC(=O)c2cnn3ccc(N[C@H]4CCS(=O)(=O)C[C@H]4N)nc23)c(n1)C(N)=O

InChI Key InChIKey=MFXJHKFTNQGRTF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311518   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM311518(US10155765, Example 4 | 5-{[cis-3-amino-1,1- dioxi...)
Affinity DataIC50: 5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
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