BDBM31140 1H-benzo[g]indole-3-carboxylate, 19

SMILES CCOC(=O)c1c(Cc2cccc(Cl)c2)[nH]c2c1cc(O)c1cc(OC)c(OC)cc21

InChI Key InChIKey=CNIYMXQGMPAJOY-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 31140   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich Alexander University Erlangen

LigandPNGBDBM31140(1H-benzo[g]indole-3-carboxylate, 19)
Affinity DataIC50: 1.00E+4nM EC50:  7.00E+3nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2009
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM31140(1H-benzo[g]indole-3-carboxylate, 19)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM31140(1H-benzo[g]indole-3-carboxylate, 19)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of mPGES1 in IL1-beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed