BDBM311152 4-((7-chloro-1-methyl-1H- indazol-4-yl)oxy)-N-(1,3,4- thiadiazol-2-yl)benzene- sulfonamide::US10155752, Compound 42::US9834543, Compound 42

SMILES Cn1ncc2c(Oc3ccc(cc3)S(=O)(=O)Nc3nncs3)ccc(Cl)c12

InChI Key InChIKey=YWEWCHPNIROOJL-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 311152   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311152(US10155752, Compound 42 | 4-((7-chloro-1-methyl-1H...)
Affinity DataIC50: 2.00E+4nMAssay Description:The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311152(US10155752, Compound 42 | 4-((7-chloro-1-methyl-1H...)
Affinity DataIC50: 2.00E+4nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311152(US10155752, Compound 42 | 4-((7-chloro-1-methyl-1H...)
Affinity DataKi:  9.01E+3nMAssay Description:The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Mediatech, Inc....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311152(US10155752, Compound 42 | 4-((7-chloro-1-methyl-1H...)
Affinity DataKi:  9.01E+3nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent