BDBM311146 (S)-2-(4-((1-methyl-1H-indazol- 4-yl)oxy)phenyl)-6-((2- oxopyrrolidin-3-yl)amino)- pyrimidine-4-carboxamide::US10155752, Compound 26::US9834543, Compound 26

SMILES Cn1ncc2c(Oc3ccc(cc3)-c3nc(N[C@H]4CCNC4=O)cc(n3)C(N)=O)cccc12

InChI Key InChIKey=URRGQBSBELLHGF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 311146   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311146(US10155752, Compound 26 | (S)-2-(4-((1-methyl-1H-i...)
Affinity DataIC50: 2.24E+3nMAssay Description:The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
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TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311146(US10155752, Compound 26 | (S)-2-(4-((1-methyl-1H-i...)
Affinity DataIC50: 2.24E+3nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
Go to US Patent