BDBM310955 US10155727, Example 8::USRE49517, Example 8

SMILES CCn1ccc(Cn2cc(cn2)-c2ccc(Cl)c(OC(F)F)c2)n1

InChI Key InChIKey=PCHBMVPVCPSMLD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 310955   

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM310955(US10155727, Example 8 | USRE49517, Example 8)
Affinity DataIC50: 281nMAssay Description:After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4° C. The pellet was resuspended in 5 ml of 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM310955(US10155727, Example 8 | USRE49517, Example 8)
Affinity DataIC50: 281nMAssay Description:After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM310955(US10155727, Example 8 | USRE49517, Example 8)
Affinity DataIC50: 4.10E+4nMAssay Description:Binding was terminated by filtration of the incubated membrane preparations using Filtermat B (Pharmacia, Uppsala Sweden) and a Micro Cell Harvester ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent