BDBM310111 US10377768, Compound 25::US9657033, Compound 25

SMILES C[C@H]1CN(c2cc(NC(=O)c3c(F)cccc3Cl)cnc2O1)S(=O)(=O)c1cccc(c1)C#N

InChI Key InChIKey=PSYACYSMVINZNE-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 310111   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310111(US9657033, Compound 25 | US10377768, Compound 25)
Affinity DataEC50:  1.03E+3nMAssay Description:Recombinant,HIS-tagged RORγ-LBD was expressed in SF9 cells using a baculovirus expression system. Cells were lysed and the lysate was used as a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310111(US9657033, Compound 25 | US10377768, Compound 25)
Affinity DataEC50:  70nMAssay Description:HIS-tagged RORγ-LBD protein was expressed in SF9 cells using a baculovirus expression system. The RORγ-LBD protein was purified by glutathi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310111(US9657033, Compound 25 | US10377768, Compound 25)
Affinity DataEC50:  1.03E+3nMAssay Description:Recombinant, HIS-tagged RORγ-LBD was expressed in SF9 cells using a baculovirus expression system. Cells were lysed and the lysate was used as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310111(US9657033, Compound 25 | US10377768, Compound 25)
Affinity DataEC50:  70nMAssay Description:HIS-tagged RORγ-LBD protein was expressed in SF9 cells using a baculovirus expression system. The RORγ-LBD protein was purified by glutathi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent