BDBM310100 (S)-2-chloro-6-fluoro-N-(3-methyl-1-(m-tolylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)benzamide ::US10377768, Compound 14::US9657033, Compound 14

SMILES C[C@H]1CN(c2cc(NC(=O)c3c(F)cccc3Cl)cnc2O1)S(=O)(=O)c1cccc(C)c1

InChI Key InChIKey=LSXDCEBRFQCIMG-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 310100   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310100(US9657033, Compound 14 | (S)-2-chloro-6-fluoro-N-(...)
Affinity DataEC50:  166nMAssay Description:Recombinant,HIS-tagged RORγ-LBD was expressed in SF9 cells using a baculovirus expression system. Cells were lysed and the lysate was used as a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310100(US9657033, Compound 14 | (S)-2-chloro-6-fluoro-N-(...)
Affinity DataEC50:  22nMAssay Description:HIS-tagged RORγ-LBD protein was expressed in SF9 cells using a baculovirus expression system. The RORγ-LBD protein was purified by glutathi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310100(US9657033, Compound 14 | (S)-2-chloro-6-fluoro-N-(...)
Affinity DataEC50:  166nMAssay Description:Recombinant, HIS-tagged RORγ-LBD was expressed in SF9 cells using a baculovirus expression system. Cells were lysed and the lysate was used as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310100(US9657033, Compound 14 | (S)-2-chloro-6-fluoro-N-(...)
Affinity DataEC50:  22nMAssay Description:HIS-tagged RORγ-LBD protein was expressed in SF9 cells using a baculovirus expression system. The RORγ-LBD protein was purified by glutathi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent