BDBM310098 2-chloro-6-fluoro-N-[1-(4-fluorobenzenesulfonyl)-2-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl]benzamide ::US10377768, Compound 12::US9657033, Compound 12

SMILES CC1COc2ncc(NC(=O)c3c(F)cccc3Cl)cc2N1S(=O)(=O)c1ccc(F)cc1

InChI Key InChIKey=NRPRHQAJUMNAPV-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 310098   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310098(US9657033, Compound 12 | 2-chloro-6-fluoro-N-[1-(4...)
Affinity DataEC50:  250nMAssay Description:Recombinant,HIS-tagged RORγ-LBD was expressed in SF9 cells using a baculovirus expression system. Cells were lysed and the lysate was used as a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310098(US9657033, Compound 12 | 2-chloro-6-fluoro-N-[1-(4...)
Affinity DataEC50:  66nMAssay Description:HIS-tagged RORγ-LBD protein was expressed in SF9 cells using a baculovirus expression system. The RORγ-LBD protein was purified by glutathi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310098(US9657033, Compound 12 | 2-chloro-6-fluoro-N-[1-(4...)
Affinity DataEC50:  250nMAssay Description:Recombinant, HIS-tagged RORγ-LBD was expressed in SF9 cells using a baculovirus expression system. Cells were lysed and the lysate was used as a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM310098(US9657033, Compound 12 | 2-chloro-6-fluoro-N-[1-(4...)
Affinity DataEC50:  66nMAssay Description:HIS-tagged RORγ-LBD protein was expressed in SF9 cells using a baculovirus expression system. The RORγ-LBD protein was purified by glutathi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent