BDBM309978 N-(2-(3-(3,4-dicyanophenyl)-1H-pyrazol-1-yl)ethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-carboxamide::US11046713, Example 52::US9657003, 52

SMILES O=C(NCCn1ccc(n1)-c1ccc(C#N)c(c1)C#N)c1cc(n[nH]1)-c1cccnc1

InChI Key InChIKey=LRXGISZWARIYOD-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 309978   

TargetAndrogen receptor(Human)
Orion

US Patent
LigandPNGBDBM309978(US9657003, 52 | N-(2-(3-(3,4-dicyanophenyl)-1H-pyr...)
Affinity DataIC50: 149nMAssay Description:Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Orion

US Patent
LigandPNGBDBM309978(US9657003, 52 | N-(2-(3-(3,4-dicyanophenyl)-1H-pyr...)
Affinity DataIC50: 149nMAssay Description:Antagonism of test compounds for AR was measured by reporter gene assay in human embryonic kidney (HEK293) cells stably transfected with an expressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2021
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Orion

US Patent
LigandPNGBDBM309978(US9657003, 52 | N-(2-(3-(3,4-dicyanophenyl)-1H-pyr...)
Affinity DataKi:  27nMAssay Description:Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetAndrogen receptor(Human)
Orion

US Patent
LigandPNGBDBM309978(US9657003, 52 | N-(2-(3-(3,4-dicyanophenyl)-1H-pyr...)
Affinity DataKi:  27nMAssay Description:Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2021
Entry Details
Go to US Patent