BDBM308046 (S)-1-(1H- benzo[d]imidazol-5-yl)-5-(4- propoxyphenyl)imidazolidin- 2-one::US9650362, 14

SMILES CCCOc1ccc(cc1)[C@H]1CNC(=O)N1c1ccc2[nH]cnc2c1

InChI Key InChIKey=XHIKZWOEFZENIX-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 308046   

TargetGlutaminyl-peptide cyclotransferase(Human)
Probiodrug

US Patent
LigandPNGBDBM308046(US9650362, 14 | (S)-1-(1H- benzo[d]imidazol-5-yl)-...)
Affinity DataIC50: 238nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase(Human)
Probiodrug

US Patent
LigandPNGBDBM308046(US9650362, 14 | (S)-1-(1H- benzo[d]imidazol-5-yl)-...)
Affinity DataKi:  25nMAssay Description:Inhibition of human recombinant glutaminyl cyclase using glutaminyl-7-amido-4-methylcoumarin as substrate assessed as inhibition constant by micropla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Probiodrug

US Patent
LigandPNGBDBM308046(US9650362, 14 | (S)-1-(1H- benzo[d]imidazol-5-yl)-...)
Affinity DataKi:  37.4nMAssay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometrical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
Go to US Patent