BDBM306786 N-(2-(3,5- difluoro-4- ((1R,3R)-2-((3- (fluoromethyl) oxetan-3- yl)methyl)-3- methyl- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1- yl)phenoxy) ethyl)-3- fluoropropan- 1-amine::US10149839, Example 72

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(CF)COC1)c1c(F)cc(OCCNCCCF)cc1F

InChI Key InChIKey=GHVZDZSXTZCJJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306786   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306786(US10149839, Example 72 | N-(2-(3,5- difluoro-4- ((...)
Affinity DataIC50: 2.40nMAssay Description:Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
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TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306786(US10149839, Example 72 | N-(2-(3,5- difluoro-4- ((...)
Affinity DataIC50: 0.470nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent