BDBM306773 2,2-difluoro-3- ((1R,3R)-1-(4- ((2-((3- fluoropropyl) amino)ethyl) amino)-2- methoxy- phenyl)-3- methyl- 1,3,4,9- tetrahydro-2H- pyrido[3,4- b]indol-2- yl)propan-1-ol::US10149839, Example 59

SMILES COc1cc(NCCNCCCF)ccc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1[nH]c1ccccc21

InChI Key InChIKey=XXFPLPRQZXGBPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306773   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306773(US10149839, Example 59 | 2,2-difluoro-3- ((1R,3R)-...)
Affinity DataIC50: 9.90nMAssay Description:Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306773(US10149839, Example 59 | 2,2-difluoro-3- ((1R,3R)-...)
Affinity DataIC50: 0.25nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent