BDBM306772 2,2-difluoro-3- ((1R,3R)-1-(4- (2-((3- fluoropropyl) amino)ethoxy)- 2-methoxy- phenyl)-3- methyl- 1,3,4,9- tetrahydro-2H- pyrido[3,4- b]indol-2- yl)propan-1-ol::US10149839, Example 58

SMILES COc1cc(OCCNCCCF)ccc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1[nH]c1ccccc21

InChI Key InChIKey=RFYOKAVMSWLCMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306772   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306772(US10149839, Example 58 | 2,2-difluoro-3- ((1R,3R)-...)
Affinity DataIC50: 1.60nMAssay Description:Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306772(US10149839, Example 58 | 2,2-difluoro-3- ((1R,3R)-...)
Affinity DataIC50: 0.0870nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent