BDBM306769 N-(2-(4- ((1R,3R)-2- (2,2-difluoro- propyl)-3- methyl- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1-yl)- 3-fluoro- phenoxy) ethyl)-3- fluoropropan- 1-amine::US10149839, Example 55

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(F)F)c1ccc(OCCNCCCF)cc1F

InChI Key InChIKey=GMGFNUDEXDJEKR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306769   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306769(US10149839, Example 55 | N-(2-(4- ((1R,3R)-2- (2,2...)
Affinity DataIC50: 1.60nMAssay Description:Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306769(US10149839, Example 55 | N-(2-(4- ((1R,3R)-2- (2,2...)
Affinity DataIC50: 0.200nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent