BDBM306761 N1-(4-((1R,3R)-2-((3-fluorooxetan-3-yl)methyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-3-methoxyphenyl)-N2-(3-fluoropropyl)ethane-1,2-diamine::US10149839, Example 47

SMILES COc1cc(NCCNCCCF)ccc1[C@H]1N(CC2(F)COC2)[C@H](C)Cc2c1[nH]c1ccccc21

InChI Key InChIKey=UXOAADVFXCLQEY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306761   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306761(US10149839, Example 47 | N1-(4-((1R,3R)-2-((3-fluo...)
Affinity DataIC50: 27nMAssay Description:Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306761(US10149839, Example 47 | N1-(4-((1R,3R)-2-((3-fluo...)
Affinity DataIC50: 0.240nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent