BDBM306752 5-chloropyrazine-2-carbaldehyde::US10149839, Example 38

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1cnc(OCCNCCCF)cn1

InChI Key InChIKey=UAQSDLXOGGADPH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306752   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306752(US10149839, Example 38 | 5-chloropyrazine-2-carbal...)
Affinity DataIC50: 1.90nMAssay Description:Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306752(US10149839, Example 38 | 5-chloropyrazine-2-carbal...)
Affinity DataIC50: 0.430nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent