BDBM306749 (5-bromo-3-methoxypyridin-2-yl)methanol::US10149839, Example 35

SMILES COc1cc(OCCNCCCF)cnc1[C@H]1N(CC(C)(C)F)[C@H](C)Cc2c1[nH]c1ccccc21

InChI Key InChIKey=WORZUPDVDMGJNB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306749   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306749(US10149839, Example 35 | (5-bromo-3-methoxypyridin...)
Affinity DataIC50: 1.80nMAssay Description:Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306749(US10149839, Example 35 | (5-bromo-3-methoxypyridin...)
Affinity DataIC50: 0.280nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent