BDBM306733 2-(3,5- difluoro-4- ((1R,3R)-2-(2- fluoro-2- methylpropyl)- 3-methyl- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1- yl)phenoxy)- N-(3-fluoro- propyl)propan- 1-amine::US10149839, Example 19

SMILES CC(CNCCCF)Oc1cc(F)c([C@H]2N(CC(C)(C)F)[C@H](C)Cc3c2[nH]c2ccccc32)c(F)c1

InChI Key InChIKey=HAYJEUZBKUSKAT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306733   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306733(US10149839, Example 19 | 2-(3,5- difluoro-4- ((1R,...)
Affinity DataIC50: 2.5nMAssay Description:Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM306733(US10149839, Example 19 | 2-(3,5- difluoro-4- ((1R,...)
Affinity DataIC50: 0.410nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
Go to US Patent