BDBM304228 2-(1-((4-carboxy-3- fluorophenyl)amino)-3- cyclobutyl-1-oxopropan-2- yl)-5-(3-chloro-6- (difluoromethyl)-2- fluorophenyl)pyridine 1- oxide::BDBM304229::US10143681, Example 119

SMILES OC(=O)c1ccc(NC(=O)C(CC2CCC2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)F)cc1F

InChI Key InChIKey=LHPWAHFZZCZBHC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 304228   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304228(BDBM304229 | 2-(1-((4-carboxy-3- fluorophenyl)amin...)
Affinity DataIC50: 80.3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
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TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304228(BDBM304229 | 2-(1-((4-carboxy-3- fluorophenyl)amin...)
Affinity DataIC50: 0.100nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304228(BDBM304229 | 2-(1-((4-carboxy-3- fluorophenyl)amin...)
Affinity DataIC50: 2.10nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent