BDBM304220 2-(1-((4- carboxyphenyl)amino)-3- (2,2-dimethylcyclopropyl)- 1-oxopropan-2-yl)-5-(3- chloro-6-(difluoromethoxy)- 2-fluorophenyl)pyridine 1- oxide::US10143681, Example 111::US10143681, Example 112

SMILES CC1(C)CC1CC(C(=O)Nc1ccc(cc1)C(O)=O)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1OC(F)F

InChI Key InChIKey=RKEDHLUVEHVMLP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 304220   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304220(US10143681, Example 112 | 2-(1-((4- carboxyphenyl)...)
Affinity DataIC50: 157nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
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TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304220(US10143681, Example 112 | 2-(1-((4- carboxyphenyl)...)
Affinity DataIC50: 0.400nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304220(US10143681, Example 112 | 2-(1-((4- carboxyphenyl)...)
Affinity DataIC50: 21.3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent