BDBM304183 2-(1-((4- carboxyphenyl)amino)-3-(3- methylcyclobutyl)-1- oxopropan-2-yl)-5-(3- chloro-2-fluoro-6- (trifluoromethyl)phenyl) pyridine 1-oxide::US10143681, Example 74::US10143681, Example 75

SMILES CC1CC(CC(C(=O)Nc2ccc(cc2)C(O)=O)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)(F)F)C1

InChI Key InChIKey=DSFAAEBGZDLQIW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 304183   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304183(2-(1-((4- carboxyphenyl)amino)-3-(3- methylcyclobu...)
Affinity DataIC50: 1.30nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
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TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304183(2-(1-((4- carboxyphenyl)amino)-3-(3- methylcyclobu...)
Affinity DataIC50: 19.2nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304183(2-(1-((4- carboxyphenyl)amino)-3-(3- methylcyclobu...)
Affinity DataIC50: 3.30nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304183(2-(1-((4- carboxyphenyl)amino)-3-(3- methylcyclobu...)
Affinity DataIC50: 77.8nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent