BDBM304179 2-(1-((4-carboxyphenyl)amino)- 3-cyclopropyl-1-oxopropan-2- yl)-5-(3-chloro-6- (difluoromethoxy)-2- fluorophenyl)-4-methoxypyridine 1-oxide::BDBM304180::US10143681, Example 70

SMILES COc1cc(C(CC2CC2)C(=O)Nc2ccc(cc2)C(O)=O)[n+]([O-])cc1-c1c(F)c(Cl)ccc1OC(F)F

InChI Key InChIKey=OUALKAWDVQPBGH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 304179   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304179(US10143681, Example 70 | BDBM304180 | 2-(1-((4-car...)
Affinity DataIC50: 0.310nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
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TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304179(US10143681, Example 70 | BDBM304180 | 2-(1-((4-car...)
Affinity DataIC50: 3.30nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304179(US10143681, Example 70 | BDBM304180 | 2-(1-((4-car...)
Affinity DataIC50: 0.470nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304179(US10143681, Example 70 | BDBM304180 | 2-(1-((4-car...)
Affinity DataIC50: 11nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent