BDBM304174 2-((2R)-1-((4- carboxyphenyl)amino)-3-(2- methylcyclopropyl)-1- oxopropan-2-yl)-5-(3-chloro-2- fluoro-6- (trifluoromethyl)phenyl) pyridine 1-oxide::US10143681, Example 65

SMILES CC1CC1C[C@@H](C(=O)Nc1ccc(cc1)C(O)=O)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1C(F)(F)F

InChI Key InChIKey=HXNUAZBSTFJGLY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304174   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304174(2-((2R)-1-((4- carboxyphenyl)amino)-3-(2- methylcy...)
Affinity DataIC50: 1.80nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
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TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304174(2-((2R)-1-((4- carboxyphenyl)amino)-3-(2- methylcy...)
Affinity DataIC50: 51nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent