BDBM304153 2-((R)-1-((4- carboxyphenyl)amino)-3- ((1S,2R)-2- methylcyclopropyl)-1- oxopropan-2-yl)-5-(3-chloro- 6-(difluoromethoxy)-2- fluorophenyl)pyridine 1- oxide::US10143681, Example 56

SMILES C[C@@H]1C[C@H]1C[C@@H](C(=O)Nc1ccc(cc1)C(O)=O)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1OC(F)F

InChI Key InChIKey=CSPPCSXVVGHDSO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304153   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304153(2-((R)-1-((4- carboxyphenyl)amino)-3- ((1S,2R)-2- ...)
Affinity DataIC50: 0.380nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
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Date in BDB:
3/30/2019
Entry Details
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TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304153(2-((R)-1-((4- carboxyphenyl)amino)-3- ((1S,2R)-2- ...)
Affinity DataIC50: 16nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent