BDBM303956 US10138242, Compound 42

SMILES OCCn1nc(C(=O)NCc2cccc3ccccc23)c2CN(Cc3ccc(Cl)cc3)CCc12

InChI Key InChIKey=GGOFNIHNFFXXOM-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 303956   

LigandPNGBDBM303956(US10138242, Compound 42)
Affinity DataEC50:  3.62E+4nMAssay Description:The assay uses two types of beads: donor beads are coupled with streptavidin, and acceptor beads are coupled with an anti His-tag antibody. Upon exci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM303956(US10138242, Compound 42)
Affinity DataIC50: 4.17E+3nMAssay Description:Antitrypanosomal activity was tested on T. brucei brucei bloodstream from parasites (strain Lister 427, VATMITat 1.2). Stock solutions of compounds (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetPeroxisomal membrane protein PEX14(Human)
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM303956(US10138242, Compound 42)
Affinity DataEC50:  8.61E+4nMAssay Description:Inhibition of biotinylated PEX5-derived ALSENWAQEFLA binding to human N-terminal His-tagged PEX14 (21 to 84 residues) expressed in Escherichia coli B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed