BDBM303823 US10138241, Example 7::US11130754, Example 7::US12139484, Example 7

SMILES CC(=O)Nc1ncc(s1)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1Cl

InChI Key InChIKey=SWAZQAVGXPTDEO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 303823   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303823(US10138241, Example 7 | US11130754, Example 7 | US...)
Affinity DataIC50: 0.990nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
Go to US Patent