BDBM30335 3-aryl isoxazole analog, 6d::CHEMBL469135

SMILES CC(C)c1onc(c1COc1ccc(\C=C\c2cccc(c2)C(O)=O)c(Cl)c1)-c1c(Cl)cncc1Cl

InChI Key InChIKey=CCOJMMHFLKMSGW-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 30335   

TargetBile acid receptor(Human)
Roche R & D Center(China)

LigandPNGBDBM30335(CHEMBL469135 | 3-aryl isoxazole analog, 6d)
Affinity DataIC50: 690nM EC50:  9.00E+3nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2009
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Roche R & D Center(China)

LigandPNGBDBM30335(CHEMBL469135 | 3-aryl isoxazole analog, 6d)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human FXR assessed as SRC1 peptide interaction with receptor ligand binding domain by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Roche R & D Center(China)

LigandPNGBDBM30335(CHEMBL469135 | 3-aryl isoxazole analog, 6d)
Affinity DataEC50:  52nMAssay Description:Agonist activity at human FXR transfected in african green monkey CV1 cells by luciferase reporter gene transient transfection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed