BDBM303175 US10137122, Compound 48

SMILES CCc1[nH]nc2c1C(c1ccccc1OC)C1=C(CC(C)(C)CC1=O)N2

InChI Key InChIKey=ZZNMVCURBNSLRA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 303175   

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303175BDBM303175(US10137122, Compound 48)
Affinity DataIC50: 100nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors Immulon 4HBX 384-well microtiter p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303175BDBM303175(US10137122, Compound 48)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303175BDBM303175(US10137122, Compound 48)
Affinity DataIC50: 550nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent