BDBM303153 US10137122, Compound 25

SMILES CSc1ccccc1C1c2c(C)[nH]nc2NC2=C1C(=O)CC(C)(C)C2

InChI Key InChIKey=SCGHSDFJYXYMBN-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 303153   

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM303153(US10137122, Compound 25)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandPNGBDBM303153(US10137122, Compound 25)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandPNGBDBM303153(US10137122, Compound 25)
Affinity DataKd:  1.24E+5nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent