BDBM302858 N-{[5-(Ethylsulfonyl)pyridine-2-yl]methyl}-5′-methyl-1-{1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}-4′,5′-dihydrospiro[piperidine-4,7′thieno[2,3-C]pyran]-2′-carboxamide::US9598431, 1

SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2cc3CC(C)OC4(CCN(CC4)C(C)c4cnc(nc4)C(F)(F)F)c3s2)nc1

InChI Key InChIKey=ILXLMNLDODDHOQ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 302858   

TargetNuclear receptor ROR-gamma(Human)
Eli Lilly

US Patent
LigandPNGBDBM302858(N-{[5-(Ethylsulfonyl)pyridine-2-yl]methyl}-5′...)
Affinity DataKi:  12nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-beta(Human)
Eli Lilly

US Patent
LigandPNGBDBM302858(N-{[5-(Ethylsulfonyl)pyridine-2-yl]methyl}-5′...)
Affinity DataKi: >1.25E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-alpha(Human)
Eli Lilly

US Patent
LigandPNGBDBM302858(N-{[5-(Ethylsulfonyl)pyridine-2-yl]methyl}-5′...)
Affinity DataKi: >2.04E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent