BDBM302224 US9598415, 136
SMILES C[C@@H](C1CC1)n1c2nc(ncc2nc(NCc2ccc(cn2)S(C)(=O)=O)c1=O)-c1c(C)ncnc1C1CC1
InChI Key InChIKey=HVVHIBHBDCYLDI-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 302224
Affinity DataIC50: 255nMAssay Description:A nuclear receptor transactivation assay is performed to quantitate the ability of test compounds to inhibit RORγ transactivation of a luciferas...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Antagonist activity at RORgamma in human PBMC assessed as inhibition of IL-22 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Antagonist activity at RORgamma in human whole blood assessed as inhibition of IL-17 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at LXR alpha (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel tail current by whole cell patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Antagonist activity at RORgamma in human whole blood derived CD4-positive T cells assessed as inhibition of IL-17 secretion from differentiated Th17 ...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Antagonist activity at GAL4 DBD-fused human RORgamma LBD expressed in pGL4.3 luc2P/GAL4UAS/hygro and pBIND transfected HEK293 cells assessed as inhib...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Antagonist activity at RORgamma in human PBMC assessed as reduction in anti-CD3/IL-23 stimulated IL-17 level measured after 3 days by MSD assayMore data for this Ligand-Target Pair