BDBM301853 N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)butyl)isoindoline-2-carboxamide ::US9598387, Compound 39::US9969743, 39

SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2Cc3ccccc3C2)CC1

InChI Key InChIKey=KUAYECUROPSOMH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 301853   

TargetD(3) dopamine receptor(Human)
Southern Research Institute

US Patent
LigandPNGBDBM301853(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Affinity DataKi:  12.2nMAssay Description:The affinities of the target compounds were determined using radioligand binding experiments. All radioligand binding experiments were performed acco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetD(3) dopamine receptor(Human)
Southern Research Institute

US Patent
LigandPNGBDBM301853(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Affinity DataKi:  12.2nMAssay Description:Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Southern Research Institute

US Patent
LigandPNGBDBM301853(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Affinity DataKi:  778nMAssay Description:The affinities of the target compounds were determined using radioligand binding experiments. All radioligand binding experiments were performed acco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Southern Research Institute

US Patent
LigandPNGBDBM301853(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Affinity DataKi:  778nMAssay Description:Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
Go to US Patent